Helen E. Collins Laboratory

Investigating Mechanisms Underlying Female Cardiovascular Resilience and Health

Introduction to the Collins Laboratory

The Collins lab is located at the University of Louisville in the Center for Cardiometabolic Science (Formerly known as the Diabetes and Obesity Center). The Centers webpage is located at www.CenterforCardiometabolicScience.org

Historically, females have been understudied in the context of preclinical and clinical trials contributing to an overall reduced knowledge of basic female cardiovascular biology and also how the female heart responds to physiological and pathological stress. Therefore, the overall mission of the Collins lab is to understand the mechanisms contributing to female cardiovascular health and resilience

Under this larger thematic focus, the Collins lab has several areas of active investigation, they include:
Understanding the mechanisms that contribute to pregnancy-induced cardiac growth and its reversal.

Pathophysiological and etiological mechanisms of peripartum cardiomyopathy and other pregnancy-associated cardiovascular complications.

The response of the female heart to pathological stressors and mechanisms underlying sex-dependent changes in post-infarction remodeling.


Coordinated Metabolic Responses Facilitate Cardiac Growth in Pregnancy and Exercise

Emily B Schulman-Geltzer, Helen E Collins, Bradford G Hill, Kyle L Fulghum

Curr Heart Fail Rep., 2023

Cardiomyocyte ZKSCAN3 regulates remodeling following pressure-overload.

Xiaosen Ouyang, Sayan Bakshi, Gloria A. Benavides, Zhihuan Sun, Gerardo Hernandez-Moreno, Helen E. Collins, Mariame S. Kane, Silvio Litovsky, Martin E. Young, John C. Chatham, Victor Darley-Usmar, Adam R. Wende, Jianhua Zhang.

Physiological Reports, vol. 11(9), 2023, pp. e15686

STIM and Orai Mediated Regulation of Calcium Signaling in Age-Related Diseases

Helen E. Collins, Dingguo Zhang, John C. Chatham

Frontiers in Aging, 2022

View all


Helen E Collins, PhD, FAHA

Assistant Professor of Medicine

[email protected]; [email protected]


Division of Environmental Medicine; Center for Cardiometabolic Science

University of Louisville

Delia Baxter Building, Room 321C, University of Louisville, 580 South Preston Street, Louisville, KY


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